Journal of Pathology and Translational Medicine

Original Articles

Pleural Mesothelioma: An Institutional Experience of 66 Cases: Soomin Ahn, In Ho Choi, Joungho Han, Jhingook Kim, Myung-Ju Ahn; Korean J Pathol. 2014;48(2):91-99. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.91

7,813 View
63 Download
2 Crossref

Background

Malignant mesothelioma of the pleura is an aggressive tumor known to be associated with asbestos. Histological diagnosis of mesothelioma is challenging and is usually aided by immunohistochemical markers.

Methods

During an 18-year period (1995-2012), 66 patients with pleural mesothelioma were diagnosed at the Samsung Medical Center in Seoul. We reviewed hematoxylin and eosin and immunohistochemical slides of pleural mesothelioma and evaluated their pathological and clinical features.

Results

The male-to-female ratio was 1.75:1, and age of patients ranged from 28 to 80 years with an average age of 56.84 years. Twenty-two out of 66 patients underwent curative pneumonectomy. Follow-up data was available in 60 patients (90.9%), and 50 of them (83.3%) died from the disease. The average overall survival was 15.39 months. Histologically, the epithelioid type was the most common, followed by the sarcomatoid and the biphasic types. Epidemiologic information was not available in most cases, and only one patient was confirmed to have a history of asbestos exposure.

Conclusions

Malignant mesothelioma of the pleura is a fatal tumor, and the therapeutic benefit of pneumonectomy remains unproven. The combination of calretinin, Wilms tumor 1, HMBE-1, and thyroid transcription factor-1 may provide high diagnostic accuracy in diagnosing mesothelioma.

Citations

Citations to this article as recorded by

Expression of V-set immunoregulatory receptor in malignant mesothelioma
Yeon Seung Chung, Moonsik Kim, Yoon Jin Cha, Kyung A Kim, Hyo Sup Shim
Modern Pathology.2020; 33(2): 263. CrossRef
Is the pathology related to the amount of pleural thickening measured by thorax CT?
özgür katrancıoğlu, Tuba Sahinoglu, Kayhan Karakus, Ozan Kandemir, Semiha Urvay, Esra Aydın Karakaya, Nurkay Katrancioglu
Cumhuriyet Medical Journal.2018; 40(2): 157. CrossRef

Usual Interstitial Pneumonia with Lung Cancer: Clinicopathological Analysis of 43 Cases: Dae Hyun Song, In Ho Choi, Sang Yun Ha, Kang Min Han, Jae Jun Lee, Min Eui Hong, Kyeongman Jeon, Man Pyo Chung, Jhingook Kim, Joungho Han; Korean J Pathol. 2014;48(1):10-16. Published online February 25, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.1.10

8,799 View
71 Download
15 Crossref

Abstract PDF

Background

Previous studies have suggested an association between usual interstitial pneumonia (UIP) and lung cancer (Ca). However, clinical and histological information is not enough to determine such an association, due to the low incidence and short survival time of patients with both conditions.

Methods

We retrospectively reviewed the clinical and histological records of Ca patients with UIP between January 1999 and August 2013 at the Samsung Medical Center, Seoul, Korea. We found 43 patients who had Ca with UIP (UIP-Ca). Previously reported data of eighty-four patients with UIP-only were included as a comparison group.

Results

Smoking is related to poor prognosis in patients with UIP-Ca, and the number of patients with a high smoking index of more than 30 pack-years significantly increased in UIP-Ca patients compared with UIP-only patients. There is no significant prognostic differentiation between UIP-Ca patients and UIP-only patients. Microscopically, UIP-Ca patients showed characteristically heterogeneous histological patterns and degrees of differentiation. There were many foci of squamous metaplasia or dysplasia at the peripheral area of squamous cell carcinomas.

Conclusions

We report 43 cases of UIP-Ca. Our results suggest that smoking is related to cancer occurrence in UIP patients and poor prognosis in UIP-Ca patients.

Citations

Citations to this article as recorded by

Prognosis of idiopathic pulmonary fibrosis without anti-fibrotic therapy: a systematic review
Yet H. Khor, Yvonne Ng, Hayley Barnes, Nicole S.L. Goh, Christine F. McDonald, Anne E. Holland
European Respiratory Review.2020; 29(157): 190158. CrossRef
Linfoma difuso de células B grandes pulmonar en paciente con neumonía intersticial no específica
Luis Gorospe Sarasúa, Paola Arrieta, Anabelle Chinea-Rodríguez, Carlos de la Puente-Bujidos
Reumatología Clínica.2019; 15(6): e151. CrossRef
Diffuse Large B-cell Lymphoma of the Lung in a Patient With Nonspecific Interstitial Pneumonia
Luis Gorospe Sarasúa, Paola Arrieta, Anabelle Chinea-Rodríguez, Carlos de la Puente-Bujidos
Reumatología Clínica (English Edition).2019; 15(6): e151. CrossRef
Characteristics of lung cancer among patients with idiopathic pulmonary fibrosis and interstitial lung disease – analysis of institutional and population data
Joo Heung Yoon, Mehdi Nouraie, Xiaoping Chen, Richard H Zou, Jacobo Sellares, Kristen L Veraldi, Jared Chiarchiaro, Kathleen Lindell, David O Wilson, Naftali Kaminski, Timothy Burns, Humberto Trejo Bittar, Samuel Yousem, Kevin Gibson, Daniel J Kass
Respiratory Research.2018;[Epub] CrossRef
Genomic profiles of lung cancer associated with idiopathic pulmonary fibrosis
Ji An Hwang, Deokhoon Kim, Sung‐Min Chun, SooHyun Bae, Joon Seon Song, Mi Young Kim, Hyun Jung Koo, Jin Woo Song, Woo Sung Kim, Jae Cheol Lee, Hyeong Ryul Kim, Chang‐Min Choi, Se Jin Jang
The Journal of Pathology.2018; 244(1): 25. CrossRef
Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study
Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Hiroyuki Ishikawa, Takehiro Watanabe, Masanori Tsuchida
BMC Pulmonary Medicine.2018;[Epub] CrossRef
Alveolar Squamous Cell Metaplasia: Preneoplastic Lesion?
Adriana Handra-Luca
Journal of Pathology and Translational Medicine.2018; 52(6): 355. CrossRef
Low expression of long noncoding RNA CDKN2B-AS1 in patients with idiopathic pulmonary fibrosis predicts lung cancer by regulating the p53-signaling pathway
Yufeng Du, Xiaoyan Hao, Xuejun Liu
Oncology Letters.2018;[Epub] CrossRef
A clinicopathological study of surgically resected lung cancer in patients with usual interstitial pneumonia
Yasutaka Watanabe, Yoshinori Kawabata, Nobuyuki Koyama, Tomohiko Ikeya, Eishin Hoshi, Noboru Takayanagi, Shinichiro Koyama
Respiratory Medicine.2017; 129: 158. CrossRef
Risk of the preoperative underestimation of tumour size of lung cancer in patients with idiopathic interstitial pneumonias
Mariko Fukui, Kazuya Takamochi, Takeshi Matsunaga, Shiaki Oh, Katsutoshi Ando, Kazuhiro Suzuki, Atsushi Arakawa, Toshimasa Uekusa, Kenji Suzuki
European Journal of Cardio-Thoracic Surgery.2016; 50(3): 428. CrossRef
The Idiopathic Interstitial Pneumonias: Histology and Imaging
Diane C. Strollo, Teri J. Franks, Jeffrey R. Galvin
Seminars in Roentgenology.2015; 50(1): 8. CrossRef
Do Chest Expansion Exercises Aid Re‐shaping the Diaphragm Within the First 72 Hours Following Lung Transplantation in a Usual Interstitial Pneumonia Patient?
Massimiliano Polastri, Erika Venturini, Saverio Pastore, Andrea Dell'Amore
Physiotherapy Research International.2015; 20(3): 191. CrossRef
Scrotal wall metastasis from a primary lung adenocarcinoma
Marie-Louise M. Coussa-Koniski, Pia A. Maalouf, Nehme E. Raad, Noha A. Bejjani
Respiratory Medicine Case Reports.2015; 15: 77. CrossRef
The Ratio KL-6 to SLX in Serum for Prediction of the Occurrence of Drug-Induced Interstitial Lung Disease in Lung Cancer Patients with Idiopathic Interstitial Pneumonias Receiving Chemotherapy
Kosuke Kashiwabara, Hiroshi Semba, Shinji Fujii, Shinsuke Tsumura, Ryota Aoki
Cancer Investigation.2015; 33(10): 516. CrossRef
Idiopathic pulmonary fibrosis will increase the risk of lung cancer
Li Junyao, Yang Ming, Li Ping, Su Zhenzhong, Gao Peng, Zhang Jie
Chinese Medical Journal.2014; 127(17): 3142. CrossRef

Bronchial Schwannomas: Clinicopathologic Analysis of 7 Cases: Yoon Yang Jung, Min Eui Hong, Joungho Han, Tae Sung Kim, Jhingook Kim, Young-Mog Shim, Hojoong Kim; Korean J Pathol. 2013;47(4):326-331. Published online August 26, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.326

7,194 View
60 Download
18 Crossref

Abstract PDF

Background

It has long been recognized that bronchial schwannomas are extremely rare. As such, diagnosing tumors in this extraordinary location can sometimes be problematic.

Methods

We reviewed seven cases of bronchoscopically or surgically resected endobronchial schwannomas and evaluated their clinical and pathologic features.

Results

The present study included five female and two male patients, with ages ranging from 16 to 81 years (mean age, 44.9 years). The clinical presentation varied according to tumor size and location. Patients with more centrally (trachea or main bronchus) located tumors experienced respiratory symptoms (80%) more often than patients with more peripherally (lobar or segmental bronchus) located tumors (0%). Histologically, the tumors were composed of spindle cells that stained with S100 protein. Some of the tumors showed typical Antoni A areas with Verocay body formation. Five of six patients (83.3%) underwent complete tumor removal by rigid bronchoscopy.

Conclusions

Pathologists should consider endobronchial schwannoma in the differential diagnosis of a spindle cell tumor involving the bronchus. Additionally, our results showed that rigid bronchoscopy is an effective tool for tumor removal in endobronchial schwannoma patients.

Citations

Citations to this article as recorded by

Video-assisted thoracic surgery for an endobronchial ancient schwannoma obstructing the left main bronchus
Jiyeon Kang, Yeon Soo Kim, Ji-Ye Kim
Journal of Surgical Case Reports.2024;[Epub] CrossRef
Two cases of large tracheobronchial schwannomas completely resected by rigid bronchoscopy with multiple instruments
Changhwan Kim, Hae‐Seong Nam, Yousang Ko
Respirology Case Reports.2023;[Epub] CrossRef
Tracheobronchial schwannoma: a case report and literature review
Guo Lina, Hou Pengguo, Xiao Zhihua, Wang Jianxin, Bai Baoqin, Zhang Mingyue, Sun Junping
Journal of International Medical Research.2023; 51(1): 030006052211498. CrossRef
Malignant and Benign Tracheobronchial Neoplasms: Comprehensive Review with Radiologic, Bronchoscopic, and Pathologic Correlation
Francis Girvin, Alexander Phan, Sharon Steinberger, Eugene Shostak, Jamie Bessich, Fang Zhou, Alain Borczuk, Geraldine Brusca-Augello, Margaret Goldberg, Joanna Escalon
RadioGraphics.2023;[Epub] CrossRef
Clinicopathological Characteristics and Pathogenesis of Granular Cell Tumours of the Airways
Jesús Machuca-Aguado, Fernando Cózar-Bernal, Enrique Rodríguez-Zarco, Juan José Ríos-Martin, Miguel Ángel Idoate Gastearena
Journal of Bronchology & Interventional Pulmonology.2023; 30(4): 390. CrossRef
Treatment of primary tracheal schwannoma with endoscopic resection: A case report
Yong-Shuai Shen, Xiang-Dong Tian, Yi Pan, Hua Li
World Journal of Clinical Cases.2022; 10(28): 10279. CrossRef
Primary bronchial schwannoma: A case report
Yosuke Aoyama, Atsushi Miyamoto, Takeshi Fujii, Sakashi Fujimori, Meiyo Tamaoka, Daiya Takai
Medicine.2022; 101(40): e31062. CrossRef
Endobronchial schwannoma in adult: A case report
Touil Imen, Boudaya Mohamed Sadok, Aloui Raoudha, Souhir Ksissa, Brahem Yosra, Ben Attig Yosr, Ksontini Meriem, Bouchareb Soumaya, Keskes Boudawara Nadia, Boussoffara Leila, Knani Jalel
Respiratory Medicine Case Reports.2021; 33: 101396. CrossRef
Primary intratracheal schwannoma misdiagnosed as severe asthma in an adolescent: A case report
Hui-Rong Huang, Pei-Qiang Li, Yi-Xin Wan
World Journal of Clinical Cases.2021; 9(17): 4388. CrossRef
PD‐1/PD‐L1 negative schwannoma mimicking obstructive bronchial malignancy: A case report
Daibing Zhou, Xiaoyan Xing, Jie Fan, Youzhi Zhang, Jie Liu, Yi Gong
Thoracic Cancer.2020; 11(8): 2335. CrossRef
Case report: A tracheobronchial schwannoma in a child
Li Zhang, Wen Tang, Qing-Shan Hong, Pei-feng Lv, Kui-Ming Jiang, Rui Du
Respiratory Medicine Case Reports.2020; 30: 101047. CrossRef
Recurrent transmural tracheal schwannoma resected by video-assisted thoracoscopic window resection
Huiguo Chen, Kai Zhang, Mingjun Bai, Haifeng Li, Jian Zhang, Lijia Gu, Weibin Wu
Medicine.2019; 98(51): e18180. CrossRef
Primary intratracheal schwannoma resected during bronchoscopy using argon plasma coagulation
Purva V Sharma, Yash B Jobanputra, Tatiana Perdomo Miquel, J Ryan Schroeder, Adam Wellikoff
BMJ Case Reports.2018; : bcr-2018-225140. CrossRef
Dumbbell posterior mediastinal schwannoma invading trachea: Multidisciplinary management – weight off the chest
Abhijeet Singh, VallandramamR Pattabhiraman, Arjun Srinivasan, Sivaramakrishnan Mahadevan
Lung India.2018; 35(3): 269. CrossRef
Primary tracheal schwannoma a review of a rare entity: current understanding of management and followup
Shadi Hamouri, Nathan M. Novotny
Journal of Cardiothoracic Surgery.2017;[Epub] CrossRef
A Case of Primary Tracheal Schwannoma
Sung Min Choi, Ji Hong You, Sang Bae Lee, Seong Han Kim, Yon Soo Kim
Kosin Medical Journal.2017; 32(2): 258. CrossRef
Endobronchial Neurilemmoma Mimicking a Bronchial Polyp
Ryoung Eun Ko, Seung Yong Park, Yeong Hun Choe, So Ri Kim, Heung Bum Lee, Yong Chul Lee, Seoung Ju Park
Soonchunhyang Medical Science.2015; 21(2): 176. CrossRef
Optimal treatment for primary benign intratracheal schwannoma: A case report and review of the literature
XIAHUI GE, FENGFENG HAN, WENBIN GUAN, JINYUAN SUN, XUEJUN GUO
Oncology Letters.2015; 10(4): 2273. CrossRef

Clinicopathological Analysis of 21 Thymic Neuroendocrine Tumors: Soomin Ahn, Jae Jun Lee, Sang Yun Ha, Chang Ohk Sung, Jhingook Kim, Joungho Han; Korean J Pathol. 2012;46(3):221-225. Published online June 22, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.221

8,315 View
74 Download
28 Crossref

Abstract PDF

Background

Thymic neuroendocrine carcinomas (NECs) are uncommon, for which there is no established information available because of a limited number of epidemiological study in Asia.

Methods

We reviewed 21 cases of surgically resected thymic NECs, and evaluated their pathological and clinical features.

Results

It showed male predominance (male/female ratio, 15/6) with wide age range from 20 to 72 years (mean age, 49 years). All 21 cases were divided into two types according to the World Health Organization criteria: atypical carcinoid (n=18) and large cell NEC (n=3). Three cases of atypical carcinoid (AC) were associated with ectopic Cushing's syndrome. All the patients (3/3) with large cell NEC (3/3) and 16.7% (3/18) of those with AC died of tumor progression. Common sites of metastasis included lung, lymph node, brain, lumbar spine, mediastinum, bone, and liver.

Conclusions

In conclusion, thymic neuroendocrine tumors carry a poor prognosis. Regarding the tumor classification, our results showed that a vast majority of carcinoids in the thymus correspond to ACs. In addition, our results also indicate that typical carcinoid is a very rare entity. Some cases of AC exhibited a large size, solid pattern and they showed aggressive clinical behavior, which highlights the spectrum of histologic appearances of thymic NECs.

Citations

Citations to this article as recorded by

Thymic neuroendocrine tumours
Jan von der Thüsen
Diagnostic Histopathology.2023; 29(2): 114. CrossRef
The Utility of Fine Needle Aspiration (FNA) Biopsy in the Diagnosis of Mediastinal Lesions
Uma Kundu, Qiong Gan, Deepak Donthi, Nour Sneige
Diagnostics.2023; 13(14): 2400. CrossRef
Paediatric and adolescent ectopic Cushing's syndrome: systematic review
Chethan Yami Channaiah, Manjiri Karlekar, Vijaya Sarathi, Anurag Ranjan Lila, Shruthi Ravindra, Padma Vikram Badhe, Gaurav Malhotra, Saba Samad Memon, Virendra Ashokrao Patil, C S Pramesh, Tushar Bandgar
European Journal of Endocrinology.2023; 189(4): S75. CrossRef
Multiple endocrine neoplasia type 1 (MEN-1) and neuroendocrine neoplasms (NENs)
Grigoris Effraimidis, Ulrich Knigge, Maria Rossing, Peter Oturai, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen
Seminars in Cancer Biology.2022; 79: 141. CrossRef
Multiple electrolyte disturbances as the presenting feature of multiple endocrine neoplasia type 1 (MEN-1)
Adrian Po Zhu Li, Sheela Sathyanarayan, Salvador Diaz-Cano, Sobia Arshad, Eftychia E Drakou, Royce P Vincent, Ashley B Grossman, Simon J B Aylwin, Georgios K Dimitriadis
Endocrinology, Diabetes & Metabolism Case Reports.2022;[Epub] CrossRef
Metastatic Thymic Carcinoid: Does Surgeon Have a Primary Role?
Kumud Gupta, Ravindra K. Dewan, Vinitha Viswambharan Nair, Rajat Saxena, Shaleen Prasad
The Indian Journal of Chest Diseases and Allied Sciences.2022; 56(4): 255. CrossRef
A resected case of large cell neuroendocrine carcinoma of the thymus
Masashi Umeda, Takahiko Misao, Tomoya Senoh, Yoshinobu Shikatani, Motoi Aoe
The Journal of the Japanese Association for Chest Surgery.2022; 36(7): 766. CrossRef
Treatment strategy and prognostic analysis of spinal metastases from thymomas: A retrospective study from a single center
Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, Siyuan Yao, Yipeng Wang, Yong Liu
Clinical Neurology and Neurosurgery.2020; 196: 106056. CrossRef
Large Cell Neuroendocrine Carcinoma of the Mediastinum Successfully Treated with Systemic Chemotherapy after Palliative Radiotherapy
Takeaki Hidaka, Saki Okuzumi, Ako Matsuhashi, Hidenori Takahashi, Kazunori Hata, Seiichiro Shimizu, Yoshinobu Iwasaki
Internal Medicine.2019; 58(4): 563. CrossRef
Surgical management of spinal metastases of thymic carcinoma
Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, William A. Li, Radhika Rastogi, Yipeng Wang, Yong Liu
Medicine.2019; 98(3): e14198. CrossRef
Resected thymic large cell neuroendocrine carcinoma: A case report and review of the literature
Shogo Ogata, Ryo Maeda, Masaki Tomita, Yuichiro Sato, Takanori Ayabe, Kunihide Nakamura
International Journal of Surgery Case Reports.2019; 60: 53. CrossRef
Metastatic or locally advanced mediastinal neuroendocrine tumours
Aadil Adnan, Shreyas Kudachi, Sudha Ramesh, Kumar Prabhash, Sandip Basu
Nuclear Medicine Communications.2019; 40(9): 947. CrossRef
Results of treatment for thymic neuroendocrine tumours: multicentre clinicopathological study†
Naoko Ose, Hajime Maeda, Masayoshi Inoue, Eiichi Morii, Yasushi Shintani, Hiroshi Matsui, Hirohito Tada, Tositeru Tokunaga, Kenji Kimura, Yasushi Sakamaki, Yukiyasu Takeuchi, Kenjiro Fukuhara, Hiroshi Katsura, Teruo Iwasaki, Meinoshin Okumura
Interactive CardioVascular and Thoracic Surgery.2018; 26(1): 18. CrossRef
Patterns of Failure Following Postoperative Radiation Therapy Based on “Tumor Bed With Margin” for Stage II to IV Type C Thymic Epithelial Tumor
Kyung Hwa Lee, Jae Myoung Noh, Yong Chan Ahn, Dongryul Oh, Jhingook Kim, Young Mog Shim, Jung-ho Han
International Journal of Radiation Oncology*Biology*Physics.2018; 102(5): 1505. CrossRef
Resected thymic large cell neuroendocrine carcinoma: report of a case
Hiromitsu Domen, Yasuhiro Hida, Masaaki Sato, Haruka Takahashi, Tatsuru Ishikawa, Yosuke Shionoya, Midori Hashimoto, Kaoru Nishiyama, Yuma Aoki, Kazuho Inoko, Syotaro Furukawa, Kazuomi Ichinokawa, Hidehisa Yamada
Surgical Case Reports.2018;[Epub] CrossRef
Successful treatment of malignant thymoma with sacrum metastases
Shuzhong Liu, Xi Zhou, An Song, Zhen Huo, William A. Li, Radhika Rastogi, Yipeng Wang, Yong Liu
Medicine.2018; 97(51): e13796. CrossRef
Incidental metastatic mediastinal atypical carcinoid in a patient with parathyroid adenoma: a case report
Zareen Kiran, Asma Ahmed, Owais Rashid, Saira Fatima, Faizan Malik, Saulat Fatimi, Mubassher Ikram
Journal of Medical Case Reports.2017;[Epub] CrossRef
Thymus neuroendocrine tumors with CTNNB1 gene mutations, disarrayed ß-catenin expression, and dual intra-tumor Ki-67 labeling index compartmentalization challenge the concept of secondary high-grade neuroendocrine tumor: a paradigm shift
Alessandra Fabbri, Mara Cossa, Angelica Sonzogni, Paolo Bidoli, Stefania Canova, Diego Cortinovis, Maria Ida Abbate, Fiorella Calabrese, Nazarena Nannini, Francesca Lunardi, Giulio Rossi, Stefano La Rosa, Carlo Capella, Elena Tamborini, Federica Perrone,
Virchows Archiv.2017; 471(1): 31. CrossRef
Thymic large cell neuroendocrine carcinoma – a rare and aggressive tumor: a case report
Efared Boubacar, Gabrielle Atsame-Ebang, Sani Rabiou, Ammor Fatimazahra, Asmae Mazti, Ibrahim S. Sidibé, Layla Tahiri, Nawal Hammas, Ouadnouni Yassine, Smahi Mohamed, Chbani Laila, El Fatemi Hinde
Journal of Medical Case Reports.2017;[Epub] CrossRef
Clinicopathological features of neoplasms with neuroendocrine differentiation occurring in the liver
Yoriko Nomura, Osamu Nakashima, Jun Akiba, Sachiko Ogasawara, Shogo Fukutomi, Rin Yamaguchi, Hironori Kusano, Masayoshi Kage, Koji Okuda, Hirohisa Yano
Journal of Clinical Pathology.2017; 70(7): 563. CrossRef
Retrosternal goiter and thymic carcinoid: A rare co-existence
Abdulsalam Yaseen Taha, Nezar A. Almahfooz, Hassanain H. Khudair
Journal of the Egyptian Society of Cardio-Thoracic Surgery.2017; 25(4): 369. CrossRef
A case of large-cell neuroendocrine carcinoma of the thymus involving a patient with long-term survival after surgery
Qiuming Kan, Kohei Tagawa, Teruaki Ishida, Mitsuyo Nishimura, Katsuhiko Aoyama
The Journal of the Japanese Association for Chest Surgery.2017; 31(7): 927. CrossRef
Neuroendokrine Neoplasien des Mediastinums
L. Brcic, M. Heidinger, H. Popper
Der Pathologe.2016; 37(5): 434. CrossRef
Outcome of primary neuroendocrine tumors of the thymus: A joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases
Pier Luigi Filosso, Xiaopan Yao, Usman Ahmad, Yilei Zhan, James Huang, Enrico Ruffini, William Travis, Marco Lucchi, Andreas Rimner, Alberto Antonicelli, Francesco Guerrera, Frank Detterbeck
The Journal of Thoracic and Cardiovascular Surgery.2015; 149(1): 103. CrossRef
Clinical Significance of Persistent Tumor in Bone Marrow during Treatment of High-risk Neuroblastoma
Young Bae Choi, Go Eun Bae, Na Hee Lee, Jung-Sun Kim, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
Journal of Korean Medical Science.2015; 30(8): 1062. CrossRef
Tumor genetics and survival of thymic neuroendocrine neoplasms: A multi‐institutional clinicopathologic study
Philipp Ströbel, Andreas Zettl, Konstantin Shilo, Wen‐Yu Chuang, Andrew G. Nicholson, Yoshihiro Matsuno, Anthony Gal, Rolf Hubert Laeng, Peter Engel, Carlo Capella, Mirella Marino, John Kwok-Cheung Chan, Andreas Rosenwald, William Travis, Teri J. Franks,
Genes, Chromosomes and Cancer.2014; 53(9): 738. CrossRef
Disseminated large cell neuroendocrine carcinoma associated with ectopic adrenocorticotropic hormone secretion
A Van der Walt, K Huddle, S Pather, A Korb
Journal of Endocrinology, Metabolism and Diabetes of South Africa.2014; 19(1): 40. CrossRef
Morphologic Alteration of Metastatic Neuroblastic Tumor in Bone Marrow after Chemotherapy
Go Eun Bae, Yeon-Lim Suh, Ki Woong Sung, Jung-Sun Kim
Korean Journal of Pathology.2013; 47(5): 433. CrossRef

Pulmonary Vascular Sarcomas: Clinicopathologic Analysis of 14 Cases.: Na Rae Kim, Jhingook Kim, Seung Yeon Ha, Joungho Han; Korean J Pathol. 2011;45(2):132-138.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.2.132

3,662 View
26 Download
4 Crossref

Abstract PDF

BACKGROUND
Pulmonary vessel sarcomas are rare, and their pathogenesis is still unclear.
METHODS
We focus on the pathologic findings of fourteen pulmonary artery and/or vein sarcomas along with clinical prognosis.
RESULTS
Nine patients were male and five were female, and they ranged in age from 26 to 72 years (mean, 47 years). There were ten cases of pulmonary artery sarcoma, three cases of pulmonary artery and vein sarcoma, and one case of pure pulmonary vein sarcoma. Ten out of the fourteen cases were associated with pulmonary thromboembolism. Microscopically, all the tumors showed an undifferentiated sarcomatous portion. There were leiomyosarcoma portions in 8 cases, malignant fibrous histiocytomatous portions in 7 cases, angiosarcomatous differentiation in 3 cases, and osteosarcomatous portion in 1 case. All but two patients died during the follow up period (range, 1 to 78 months). The mean survival time of the patients who died was 14 months and the longest survival time was 78 months after surgical resection.
CONCLUSIONS
The current study is one of the largest single institutional reviews of pulmonary artery and/or vein sarcoma. Regardless of the histological components and macroscopic growth patterns, these rare tumors have a grave prognosis.

Citations

Citations to this article as recorded by

Therapeutic Use of Bee Venom and Potential Applications in Veterinary Medicine
Roberto Bava, Fabio Castagna, Vincenzo Musella, Carmine Lupia, Ernesto Palma, Domenico Britti
Veterinary Sciences.2023; 10(2): 119. CrossRef
Intimal Sarcoma of the Great Vessels
Alan M. Ropp, Allen P. Burke, Seth J. Kligerman, Jay S. Leb, Aletta A. Frazier
RadioGraphics.2021; 41(2): 361. CrossRef
Incidence of pulmonary non-epithelial tumors: 18 years’ experience at a single institute
In Ho Choi, Dae Hyun Song, Kang Min Han, Yong Soo Choi, Joungho Han
Pathology - Research and Practice.2014; 210(4): 210. CrossRef
Pleomorphic Malignant Histiocytoma of Pulmonary Arteries Presenting as Pulmonary Aneurysms
Gustavo Armando De La Cerda Belmont, Carlos Alberto Lezama Urtecho
The Annals of Thoracic Surgery.2013; 95(3): 1091. CrossRef

Alveolar Soft Part Sarcoma of the Lung: A Report of Six Cases and Clinicopathological Analysis.: Na Rae Kim, Mi Sook Lee, Young Cheol Yoon, Dae Su Kim, Kyong Soo Lee, Gee Young Suh, Jhingook Kim, Joung Ho Han; Korean J Pathol. 2003;37(2):87-92.

1,699 View
25 Download

Abstract PDF: BACKGROUND
Alveolar soft part sarcoma (ASPS) accounts for 0.5-1% of soft tissue sarcomas, and often metastasizes to the lung. Cases of pulmonary ASPS of unknown primary site have rarely been reported in literature.
METHODS
Here, we report three cases of metastatic pulmonary ASPS and three cases of presumably primary ASPS using immunohistochemistry and clinicoradiologic findings.
RESULTS
All of the cases occurred in young females. Two of the cases had metastasized from soft tissue ASPS of the lower extremities, and one case had metastasized from one of the patient? femur bones. Immunohistochemical stains were applied to four cases that had available paraffin blocks. The tumor cells of all cases on which immunohistochemical stains were done were positive for vimentin (4/4, 100%). None of the tumors were positive for myoglobin, desmin, smooth muscle actin, progesterone receptor, estrogen receptor, thyroid transcription factor-1, S-100 protein, pancytokeratin, and HMB-45 antibodies.
CONCLUSION
The present study revealed that the rare pulmonary ASPS has nonspecific clinicoradiologic findings. In the immunohistochemical results, no differences existed between the presumably primary ASPS and the metastatic ASPS except for a higher Ki-67 labeling index in the latter (less than 0.1% vs. 30%). The higher index was not dissimilar to those of the extrapulmonary ASPS which showed a tumor with a low proliferation index, signifying a better prognosis and have a low potential to metastasize.

Case Reports

Solitary Pulmonary Mixed Squamous Cell and Glandular Papilloma: A Brief Case Report.: Chan Ohk Sung, Jhingook Kim, In Gu Do, Joungho Han; Korean J Pathol. 2008;42(6):393-395.

1,695 View
10 Download

Abstract: Pulmonary mixed squamous cell and glandular papillomas are extremely rare-only a few cases have been reported worldwide. We report a case of mixed squamous cell and glandular papilloma that presented as a solitary pulmonary nodule in a 53-year-old man. The tumor was located in the peripheral small bronchus of the posterobasal segment of the right lower lobe. Microscopically, the tumor was composed of papillary structures lined by squamous and glandular epithelium with mucous material. The fibrovascular cores showed lymphoplasmacytic infiltrates.

Placental Transmogrification of the Lung: A Brief Case Report.: Eun Su Park, Joungho Han, Won Jung Koh, Kyung Soo Lee, Jhingook Kim, Jinwon Seo, Jiyoung Kim; Korean J Pathol. 2008;42(5):308-310.

1,852 View
40 Download

Abstract PDF: Placental transmogrification (PT) is an unusual condition in which the alveoli develop a peculiar villous configuration that resembles the placental villi. We report a rare case of pulmonary PT in a 46-year-old man who presented with multiple cystic lesions and nodules on radiography. The patient was treated with a surgical excision. The cut surface of the lung lesion had a villous spongiform manifestation with a partly yellow granular appearance. Microscopically, multiple papillary cores mimicking the villous structures of the placenta were observed within the bullous airspaces. These papillary cores contained many vascular structures, lymphoid aggregates, interstitial clear cells, mature fat and dystrophic calcification. This case was solitary and not associated with other pulmonary or systemic diseases. The etiology is unknown, and further studies will be needed to understand the pathogenesis of the lesion.

First
Prev
Page of 1
Next
Last

Search